Newsletter | October 21, 2025

10.21.25 -- Making The Leap To Smart Bioprocessing

SPONSOR

Webinar: Enhancing Non-Viral CAR T Manufacturing with MaxCyte Electroporation and Akadeum Microbubble T Cell Isolation

Unlock the future of engineered T cell therapies! Join MaxCyte's webinar to discover how pairing our proven electroporation platform with Akadeum’s innovative microbubble isolation can deliver higher yields, greater viability, and superior efficiency in non-viral CAR T workflows. Don't miss practical insights to streamline your processes and accelerate results—register today! Click here to learn more.

FOCUS ON MANUFACTURING

Making The Leap To Smart Bioprocessing

A European consortium achieved greater T cell expansion compared to baseline conditions using real-time process monitoring and control.

Facts About AAV Producer Cell Lines

Gene therapies are revolutionizing medicine, with AAV vectors leading the way. As production evolves, stable cell lines may replace transient transfection and unlock scalable solutions.

Purification Of Complex mAb Modalities: Ask The Specialists

Traditional mAb purification methods often fall short with complex modalities. Discover how experts tackle new impurities and structural complexities to enhance therapeutic antibody purification.

The Power Of 3: How Triple Stack Incubators Can Help Optimize Your Lab

Maximize your lab’s efficiency without sacrificing space. See how triple-stack incubators help scale operations, run multiple experiments, and streamline workflows within a compact footprint.

Tips For Designing A Single-Use Manifold For Advanced Therapies

Expert single-use engineers address six common questions posed by cell and gene therapy manufacturers in the design of custom single-use manifolds for the critical handling of biological fluids.

Flexibility And High-Quality Extraction Of Genomic DNA And RNA

In this report, we analyze the quality and quantity of gDNA as well as RNA from S. cerevisiae with Pall NAB Nanosep centrifugal devices in comparison with a renowned commercial brand.

Functional And Phenotypic Characterization Of Human NK Cells Post-Expansion

A new method for expanding natural killer cells provides a way to generate a large quantity of potent cells for clinical applications. This approach maintains key cell functions and killing ability.

Automating The Process Of Filling Media Into Bottles

Learn how a vaccine manufacturer using a wide range of containers for media and buffer filling was able to increase efficiency by 70% with an automated closed-system solution.

Key Processes Of The T Cell Therapy Workflow In Chemically Defined Media

Delve into how chemically defined media supports robust cell expansion and function across key T cell therapy workflow steps, including a wash-free cryopreservation and thaw process for simplified scale-up.

A Platform Standard For Viral Vector Manufacturing And Commercialization

Examine the details of several platform technologies currently being developed and implemented to support effective, large-scale production of viral vectors that meet set quality attributes.

How To Successfully Control The Upscaling Of Your LNP Formulation

Read key strategies for controlling LNP formulation and upscaling. Understand the science behind lipid nanoparticles, critical parameters, and achieving effective turbulent mixing for optimal outcomes.

Accelerating CGT Scale-Up With An Advanced Manufacturing Platform

By exploring the integration of advanced manufacturing platforms, you can acquire how to improve biological performance and leverage the economic and operational benefits of closed systems.

Innovative Therapeutic Applications Of Ion Exchange Resins

Chromatography resins are aiding in the delivery of cancer and inflammatory disease therapies. Learn how ion exchange resins act as therapeutic carriers for advanced drug delivery.

Data-Driven CHO Bioprocess Optimization And Scale-Up

Get information on how at-line cell culture media analysis enhances mAb production by refining nutrient feed strategies, reducing toxic metabolites, and improving yields while lowering costs.

SPONSOR

Webinar: Is Your Media Silently Holding You Back? The Case for Optimized and Excipient GMP Cell Culture Solutions

This webinar explores how QuickStart Media™ simplifies custom media development with pre-optimized, customizable formulations for various cell types, accelerating timelines and reducing costs. Learn how Nucleus Biologics’ Excipient GMP manufacturing—with ISO-certified facilities and clean rooms—ensures consistency, compliance, and quality. Click here to learn more.

MANUFACTURING SOLUTIONS

Optimize Your RNA-LNP Delivery With Ionizable Lipids - Cytiva

Is Your Current AAV Process Holding You Back? - Mirus Bio

CellThera™ Leads The Way: Innovation In Gamma Delta T Cell Media - ACROBiosystems

Aseptic Containment Isolator For Compounding - Germfree

A Proven Combination For AAV Production - Sartorius

EVENTS

Advancing the Future of Cell & Gene Therapy

This 11-12 November, Cell 2025 unites 1,000+ leading experts across the CGT value chain to solve key challenges, from scalable bioprocessing and regulatory hurdles to accelerating development timelines.

 

Gain practical strategies across cell culture, therapy development, and CGT manufacturing, and hear from world-renowned leaders Bobby Gaspar (CEO, Orchard Therapeutics), Christof Von Kalle, (Director & BIH Chair, Research Clinic Luxemburg), and Dame Molly Stevens (University of Oxford). Register Now

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